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PubMed, Yue, Xiao, et al

Research shows that glutathione can help to reduce neurodegenerative disease, promote cartilage health, ward off age-related changes in the eye, improve immune function, and maintain more youthful skin

Adding an epitranscriptomic layer to this cycle, m6A RNA hypomethylation, driven by reduced METTL3 expression in substantia nigra dopaminergic neurons, impairs mitochondrial biogenesis through downregulation of the mtDNA transcription factor Tfam, while the resulting mitochondrial dysfunction reciprocally suppresses m6A deposition, creating a self-perpetuating pathogenic loop [88]

A ketogenic diet and the treatment of autism spectrum disorder