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REDEFINE-1: Phase 3 Pivotal Trial (NCT05064293) Study Title: "Efficacy and Safety of CagriSema in Adults With Overweight or Obesity (REDEFINE 1)" Status: Completed (Results Published 2024) Phase: Phase 3 Enrollment: 3,400+ participants Study Period: 2021-2024 Location: Global, 15+ countries Design: Randomized, double-blind, active-controlled Duration: 68 weeks Intervention: CagriSema (cagrilintide 2.4mg + semaglutide 2.4mg) vs

CARDIOVASCULAR RISK These findings clearly made it attractive to exploit the GLP-1 hormone for diabetes therapy and, indeed, a continuous subcutaneous infusion of GLP-1 over six weeks produced marked reductions of glycated haemoglobin and improvements in beta cell function along with weight loss in people with advanced T2DM [12]

Some scientific evidence also points to niacin helping with heart disease including clogged arteries

10.1042/EBC20170104 Essays Biochem

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