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Furthermore, the trim and fill model did not identify any missing studies, corroborating the robustness of the findings

In January 2026, the MHRA authorised an increase to a maximum weekly dose of 7.2 mg for certain adults with obesity

Healthcare providers should evaluate for adverse effects, review medication adherence, and reinforce lifestyle modifications including nutrition and physical activity

This is especially helpful with regard to laboratory research, where long-term and repeated activity is required to examine relative changes in glucose regulation, insulin sensitivity, and metabolic signaling