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These derivatives exhibited dramatically enhanced hypoxic cytotoxicityshowing between 9.5- and 30.9-fold greater potency compared to TPZ, while preserving hypoxia selectivity

Dogs taking the supplement, which provided 225 mg of SAMe and 82 mg of silybin-phosphatidylcholine complex (24 mg of silybin) per day, throughout chemotherapy were less likely to exhibit increased biomarkers of liver damage and were less likely to have their chemotherapy treatments delayed due to increased liver enzyme activity