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These results confirm and extend the finding in STZ diabetic rats [95], suggesting that dietary non-iron supplements may partially prevent the development of peripheral diabetic neuropathy (PDN) [96]

Thats a big deal because it suggests semaglutide may be boosting heart health directly, perhaps in addition to the typical benefits that accompany weight loss, says Caroline Apovian, an obesity medicine specialist at Harvard Medical School and Brigham and Womens Hospital in Boston

People who continued GLP-1 use for 2 years and 2.5 years, before then discontinuing, had a 7% reduced risk of major adverse cardiovascular events than people in the sulfonylurea group

This increases the risk of developing kidney stones