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Primary Effect of Lurcher Mutation and Cell Death Mechanisms There are two different Lurcher mutations, Grid2 Lc and Grid2 Lc J , both being base pair point mutations (G-to-A substitution) between markers D6Rck353-D6Rck357 and D6Rck314-D6Rck361 respectively, changing a non-polar alanine to polar threonine (A654T) in the transmembrane domain III, leading to the leaky GluR2 and both causing similar phenotype [16, 17, 79]

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In China, approximately 44% of migraine patients experience inadequate symptom relief following acute treatment (Zhang et al., 2023)

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