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85 This was also supported by Ravi et al., who had reported that smoke exposure resulting from cooking, heating, or smoking (whether direct or passive), as well as direct inhalation of gas, was most strongly associated with cleft palate: 60.7% in unilateral cleft palate, 90.9% in bilateral cases, 65.0% in soft tissue, and 76.2% in hard tissue cleft palate

In parallel, gut-resident T cells conditioned by the microbiota (for instance, pro-inflammatory Th17 cells versus anti-inflammatory regulatory T cells) can traffic to the CNS [38]

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