The copper coordination chemistry of GHK-Cu enables controlled cellular copper delivery while preventing the formation of reactive oxygen species characteristic of free copper toxicity, with the peptide's binding affinity (log K = 16.1) positioning it perfectly within the physiological copper transport hierarchy to facilitate controlled metal transfer to enzymatic targets including lysyl oxidase (essential for collagen cross-linking) and superoxide dismutase (critical for antioxidant defense)
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Furthermore, the Co NSs/rGO/SPCE sensor presented good capability to investigate the ascorbic acid, salicylic acid, and glutathione levels in real samples with satisfactory recoveries
Nicolai et al., 2021)
Accessed 18 Oct 2023 Zeidan J, Fombonne E, Scorah J, Ibrahim A, Durkin MS, Saxena S, Yusuf A, Shih A, Elsabbagh M (2022) Global prevalence of autism: a systematic review update