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This, in turn, has been demonstrated to result in the up-regulation of PD-L1 expression, the reduction of CD4 and CD8 T-cell activation and tumor infiltration, and the promotion of the growth of pancreatic ductal adenocarcinoma (PDAC) cells [112]

Increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes, especially those who also take medicines for type 2 diabetes such as sulfonylureas or insulin

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4), for example, an excess of an organic acid, -hydroxybutyric acid (GHB), is detected, not succinic semialdehyde, the intermediate that accumulates as a result of a LoF mutation in ALDH5A1