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Supply shortages, insurance coverage changes, or cost differences between compounded semaglutide and affordable tirzepatide options can force people to switch between them out of necessity rather than strategy
Common Semaglutide side effects include: Nausea or vomiting Diarrhea or constipation Reduced appetite Headaches Hair Loss Gas Bloating Stomach Pain Gallbladder disease Allergic reactions More serious, but less common, side effects can occur
The estimated hazard ratio (95% CI) was 0.80 (0.72, 0.90) (see Figure 2 and Table 6)
It is a dual GIP and GLP-1 receptor agonist.14 This means it mimics the actions of both GLP-1 and another incretin hormone called glucose-dependent insulinotropic polypeptide (GIP)
In Quebec, where one in four adults is obese, the current cost of these new drugs (approximately $500 per month) would involve an annual expenditure of several hundred million dollars (in the United States the situation is even worse: the cost of a 72-week course of tirzepatide (15 mg/week) is approximately US$17,000, while the 68-week treatment with semaglutide (2.4 mg/week) is nearly US$23,000!)
