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When it does happen, you usually have another condition such as: Endocrine disorders, such as Addison's disease, Cushing's syndrome, and hyperthyroidism Lupus Metabolic disorders, such as alcaptonuria Hyperbilirubinemia (in which you can't break down bilirubin) Rare genetic problems, such as porphyria, Touraine syndrome, or Laugier-Hunziker syndrome Tumors Active melanocytes can form longitudinal melanonychia because of noncancerous and cancerous tumors

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The same goes for intranasal forms, generally