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SEMA was shown to be the most effective of its category in terms of meaningful weight reduction as it can penetrate certain areas in the central nervous system that are critical for hunger and appetite control and are not protected by the blood-brain barrier, regulating key appetite-modulating relay areas [70, 73]

It tells the pancreas to release insulin when blood sugar is high, slows how fast the stomach empties, The short version: tirzepatide is approved and hits two receptors (GIP and GLP-1)

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