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Since these medications have established safety profiles in approved metabolic indications, researchers feel they could potentially be repurposed for addiction treatment more quickly than entirely new drugs, although safety and tolerability in people with alcohol or substance use disorders still require dedicated testing
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DPP-4 cleavage of GLP-1 hGLP-1, pGLP-1, eGLP-1 and Ex-4 (30 M) were incubated with DPP-4 (3 U/L) in sodium phosphate buffer (0.1 M, pH 7.4) for 0, 30, 60, 90 and 120 min in 37 C incubator, respectively, when trifluoroacetic acid (TFA, 0.1%) was added to terminate the reactions
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