15-18 Under normal circumstances, this toxic metabolite reacts with sulfhydryl groups in glutathione, converting it to harmless metabolites before being excreted in the urine
Staff raised concerns about incomplete characterization, manufacturing-related impurities, aggregation and immune reactions, limited clinical evidence, uncertain effectiveness, and gaps in long-term safety data
Funding This study was supported by the National Natural Science Foundation of China (82260459, 82303342, 82203075, and 82460600), the Natural Science Foundation of Jiangxi Province (20224BAB216068 and 20212BAB216029) and the Health Commission science and technology plan project of Jiangxi province (202210033)
Lactobacillus reuteri tryptophan metabolism promotes host susceptibility to CNS autoimmunity
10.1016/j.neurobiolaging.2018.06.038 Neurobiol