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Extrapolation between rodent, canine, primate, and human oral bioavailability is challenging and requires allometric scaling

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Nicotinamide N-methyltransferase (NNMT) in health and disease. Cellular and Molecular Life Sciences

For wound healing or localized tissue repair, injecting near the target area may improve local bioavailability

This study, together with reference 50, uses quantitative analysis of neuronal morphology and theoretical modelling to suggest that the layout of the dendrites and axons of neocortical pyramidal neurons appears to achieve all-to-all potential connectivity with neighbouring pyramidal cells