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however, none has achieved consistent clinical efficacy or routine adoption in vascular practice.3137 Mannitol, administered prior to ACCEPTED MANUSCRIPT ARTICLE IN PRESS ARTICLE IN PRESS revascularization, has been used clinically as an osmotic agent and free- radical scavenger in acute limb ischemia and has been associated with improved limb salvage and reduced mortality.20 However, the supporting evidence remains observational, and effective dosing carries a significant risk of acute kidney injury

When the muscles responsible for moving food and waste through the digestive tract are not functioning properly, bacteria can accumulate in the small intestine, leading to overgrowth

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The combination treatment resulted in significant reduction in lipid peroxidation and pathologic -synuclein accumulation in the SNpc neurons of the MPTP-treated mice