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In multiple rodent models of chronic stress (a shared risk factor for major psychiatric illnesses), administration of LAC leads to a rapid and persistent antidepressant-like response by increasing histone acetylation and expression of key genes, including mGlu2 receptors and the downstream brain-derived neurotrophic factor BDNF [27, 30, 34,35,36,37]

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Many individuals undergoing the gastric sleeve procedure have experienced an improvement in sleep apnea and other medical issues connected to obesity

Ondansetron (4 to 8 mg orally as needed, up to 3 times daily) is commonly used off-label in this setting