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Results We show that our model accurately reproduces published clinical and experimental data on the dose-dependent time course of acetaminophen in the plasma, the accumulation of acetaminophen and its metabolites in the urine, and the depletion of glutathione caused by conjugation with the toxic product

Additionally, secondary BAs exhibit strong antimicrobial activity (93, 94), and exert protective effects on gout by suppressing inflammatory responses through TGR5-mediated downregulation of the NF-B signaling pathway (101)

The condition is known to negatively affect ocular comfort, visual function, and overall quality of life [330]

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Braidy, N., Lim, C