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doi: 10.1038/s41563-019-0462-9 207 FurusawaYObataYFukudaSEndoTANakatoGTakahashiDet al

Efficacy and safety of oral sildenafil in the treatment of erectile dysfunction: a double-blind, placebo-controlled study of 329 patients

The extracellular citrulline autoantigen present in the joints of RA patients is mainly derived from the increased NET, which can cause the inflammatory response of synovial fibroblasts in patients and release a series of inflammatory mediators (such as pro-inflammatory cytokines, adhesion molecules and chemokines) to drive the progression of RA (205)

It is associated with collagen synthesis, improved skin structure, and enhanced cellular renewal signalling