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B12 is included for energy and because it is cheap, well tolerated and gives the injection a perceptible effect though only patients who are actually deficient should expect a real energy change from it

The authors have investigated three treatments to correct metabolic abnormalities which have demonstrated improvement in behavior and/or metabolism, namely the combination of methylcobalamin (mB12) with low-dose folinic acid (LDFA) to treat oxidative stress in an open-label study (James et al., 1A demonstrates where these agents are believed to act within four major interconnected metabolic pathways that are known to be disrupted in ASD