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What they found (summary): NAD+ levels decline linearly with age in all tissues Sirtuins are glucose sensors , activated during caloric restriction and fasting The decline in NAD+ leads to pseudohypoxia in aging cells Supplementation with NAD+ precursors in animal models restores sirtuin activity Therapeutic perspectives: NMN, NR, sirtuin activators, CD38 inhibitors Why it matters: This is the reference article for the entire field
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10.1097/ICO.0000000000001181 Summary Keywords cytokines, dry eye syndromes, glaucoma, glutathione, lubricant eye drops, wound healing Citation Gallo Afflitto G, Fanelli M, Petrone V, Chirico R, Ceccarelli F, Martucci A, Minutolo A, Aiello F, Garaci E, Matteucci C and Nucci C (2026) Efficacy of hyaluronic acid and butyroyl glutathione in the management of glaucoma-related ocular surface disease: a prospective, interventional, double-blind, cross-over post market study
Improper or prolonged glutathione use may affect kidney health in some individuals, particularly those with existing kidney-related conditions
