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Treatment of AS mice with P-Mn/TI@mHSA The prophylactic and therapeutic efficacy of P-Mn/TI@mHSA against atherosclerotic plaques was evaluated

In addition, pro-inflammatory cytokines can act to steal tryptophan away from serotonin and melatonin pathways (via up-regulation of the enzymes IDO and TDO), increasing the activity of the NMDA agonist quinolinic acid, and further antagonising stimulation of NMDA pathways, which subsequently exacerbates mood and sleep issues