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The Cochrane database of systematic reviews 2018
K.SeethamrajuH.DhodyK.CorleyM
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This broad receptor engagement profile means that Melanotan II simultaneously activates melanogenic pathways (MC1R on melanocytes), appetite and energy homeostasis circuits (MC3R/MC4R in hypothalamus), and exocrine gland function pathways (MC5R), making it essential for researchers to design appropriate controls and selective antagonists into experimental protocols to attribute observed effects to specific receptor subtypes
The weight loss continued steadily for 65 weeks and stayed stable throughout the whole ordeal
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