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The hyperglycaemic effect is dose-dependent and typically most pronounced in the afternoon and evening, several hours after morning prednisolone administration

However, in the long run, using the foods will be a more natural way to achieve a balanced level

You run the risk of developing heat exhaustion, heatstroke, and dehydration

We therefore conclude that before the place of GLP-1/glucagon co-agonists within the therapeutic armamentarium can be defined, future research efforts need to address the following outstanding questions: What is the optimal balance and receptor potency of GLP-1 and glucagon in a long-acting co-agonist, to minimise adverse effects and to optimise efficacy ( Figure 2 )

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