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Further investigations are needed to determine the value of H3K27me3 as a predictive marker for establishing sensitivity to epigenetic-based therapies (EZH2 inhibitors, BRD4 targeted therapies) in tumors such as malignant peripheral nerve sheath tumor and melanoma

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In this study, we report that a select set of metabolites, such as phosphoenol pyruvate (PEP), glutathione (GSH), 2-hydroxyglutarate (2-HG), and NAD + , display significant differences between the healthy and diseased motor cortex with TDP-43 pathology at a symptomatic stage