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Taking too much phentermine over time can lead to chronic intoxication, which can cause trouble sleeping, irritability, personality changes, hyperactivity, psychosis (similar to schizophrenia), and severe skin problems

5,6 However, persistence appears to be improving

Beyond changes in caloric intake, 4 studies evaluated changes in macronutrient intake [16,18,25,29]

The anti-inflammatory effects involve inflammatory mediator and signaling pathway suppression

The healthy heart has metabolic flexibility, enabling mitochondria to adaptively utilize different substrates depending on oxygen levels, substrate concentrations, and enzyme activity to produce ATP that meets cardiac needs, with fatty acids being the most productive substrate (Xu et al., 2018), though its exact therapeutic mechanism remains unclear