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Results showed that in PA-treated HUVECs and HFD-fed ApoE / mice, combination of metformin and liraglutide at lower dose significantly improved endothelial dysfunction compared with the single treatment

Ovarian enlargement or ovarian cyst formation may be more likely to occur in patients with polycystic ovary syndrome or in those patients on higher cyclic dosages, receiving treatment beyond 5 days in each cycle, or receiving more than six total cycles of therapy

So more is not better, which I think applies to a lot of things in 2024 and 2025

Some researchers exploring microdosing schedules suggest that doses as low as 1 to 2 mg weekly may provide measurable anti-inflammatory effects with minimal metabolic impact and side effects

Certain oral GLP-1s need to be taken on an empty stomach with specific timing