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At baseline, the mean age was 55 years (range 19 to 84), 51% were female, 62% were White, 26% were Asian and 8% were Black or African American

Although HIF-1 does not directly regulate the transcription of glutaminolysis-related genes to the same extent as glycolytic genes, indirect modulation through signaling pathways influenced by HIFs has been reported (98)

The increase in free fatty acids in poorly controlled diabetes is associated with an increase in fatty acids attached to the LDL particle, a further potential cause for increased oxidation of the particle [13]

10.1186/s12882-017-0673-8 209 ZhangJ.BiR.MengQ.WangC.HuoX.LiuZ.et al (2019)

For patients with neurological involvement, maintenance injections are typically given every 2 months