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Some common but typically mild side effects may include: Nausea Diarrhea Vomiting Fatigue Constipation Decreased appetite Headache These side effects are generally well-tolerated by patients and tend to decrease over time as the body adjusts to the medication

Downregulation of ASS1 caused by promoter methylation increases the susceptibility of tumor cells to PEGylated arginine deiminase (ADI-PEG20) (Table 1), a drug for arginine-deprivation treatment that has been used in clinical trials for a variety of tumors (Delage et al., 2012

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