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Grouping: Sham group (physiological saline), OVX control group (physiological saline), AOD 9604 Capsule low-dose group (100 g/kg/day), AOD 9604 high-dose group (500 g/kg/day), positive drug group (teriparatide, 20 g/kg/day)

Because it does not suppress appetite, it can theoretically be combined with GLP-1 agonists to add a lipolytic component to the appetite suppression mechanism, though clinical data on this combination is lacking

In addition, we observed an upregulation of 1030-fold for SCD, LIPIN1, and DGAT2 genes in low B12 primary Sc adipocytes derived from subjects with overweight and an increase of 20-fold for DGAT2 from subjects with morbid obesity (Fig

This regulation is particularly significant in managing fat metabolism and energy utilization