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In another study, GLP-1 and exendin-4 treatment was shown to normalize the altered vascular tone in type 2 diabetic rats, with the latter being less effective [115]

Interestingly, monomeric GLP-1R agonists, like semaglutide and liraglutide, as well as dual GLP-1R agonists like tirzepatide, have been FDA-approved for the treatment of T2DM and metabolic disorders, including chronic weight management in adults with obesity [32,33]

Because lactic acid molecules are larger than glycolic acid, they dont penetrate as deeply

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