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For the newer-generation therapies there was increased risk of nausea compared with placebo: semaglutide relative risk (RR) 2.95 (95% CI 2.613.32), tirzepatide RR 2.90 (95% CI 24.19), and orforglipron RR 4.77 (95% CI 2.0211.31)

Biochemistry 46 , 76657677 (2007)

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These side effects include but are not limited to: The Gallery of Cosmetic Surgery offers a nutrition program for patients taking oral tirzepatide for weight loss