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Cheng FS, Lei JX, Zhang J et al (2025) Global burden of Alzheimer disease and other dementias reveals escalating geographical disparities and metabolic risks: a comprehensive analysis of 1990-2021 data

For example, sugar alcohols like sorbitol or mannitol (used in some chewable or effervescent preparations) can have osmotic effects, drawing water into the intestinal lumen and potentially leading to loose stools in sensitive individuals

Cons: Effects arent consistently strong across populations

Consistent signaling: Encourages sustained lipolysis Reduces fat regain risk Supports long-term metabolic adaptation Interrupting that signal arbitrarily works against the goal

Further research, including controlled studies with proper single-compound comparison groups, is needed to validate any combined effect