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This isn't because 1:1 is mechanistically optimal in some provable way it's because researchers studying combinations of these compounds chose 1:1 as the default and the literature accumulated around that choice

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Push the needle through the vials stopper and inject the air insidethis helps equalize the pressure and makes drawing the liquid easier

This will help you avoid using too much or too little bac water, which can lead to a host of problems

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