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h , Immunoblot of indicated proteins in HeLa cells treated with indicated doses of H 2 O 2 for 24 h

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Supported in part by Award Number P30 CA006927 from the National Cancer Institute of the National Institutes of Health

In conclusion, we revealed novel structurefunction relationships of glutaredoxins, gained insights regarding the enzymatic conversion of glutathione- and non-glutathione disulfide substrates, and identified two distinct substrate interaction sites that include a scaffold residue and the conserved dual activator Lys105 in ScGrx7 and Lys26 in PfGrx

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