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To mitigate any potential negative effects on methylation, additional interventions can support the methyl cycle while using folinic acid therapy: Improving SAH (S-adenosylhomocysteine) levels by reducing homocysteine through methyl donors like betaine (TMG), vitamin B6 (P5P), and methylcobalamin (B12)

The eight vitamins that make up the B complex include: For breastfeeding parents, these vitamins are particularly important because many of them are considered "Group I" nutrients

In: MotherToBaby, ed

However, in children with Down syndrome, one study found red blood cell folate was lower than serum folate

Fate of cobalamins in humans following oral and intramuscular administration of cyanocobalamin, hydroxocobalamin, adenosyl-cobalamin and methylcobalamin