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Scott Isaacs, MD, FACP, FACEs Post Reduced-frequency GLP-1 as a maintenance strategy: in this case series, patients who tapered from weekly semaglutide/tirzepatide to less frequent dosing maintained weight loss, body composition, and metabolic syndrome gains, supporting structured de-escalation to lower burden without sacrificing efficacy

However, results depend on individual factors such as metabolism and activity level

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The mechanism through which they are coupled is not obvious from our structures alone, though we hypothesise that the two glutamine residues previously identified as important for sodium-dependent transport 46 , Q180 and Q207, play a role in linking the Na + and carnitine sites