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The hypothesis suggests that PCs activate the S100A11/RAGE/PPAR signaling pathway, resulting in reduced RAGE expression and alleviation of cardiac fibrosis triggered by AGEs in type 2 diabetic rats (Luan et al., 2014)
By contrast, no significant differences were observed in response to GEP12 at 5 nmol/kg/day (food intake: mean difference 20.0 kcal/day, 95% CI 41.4 to 1.5 kcal/day, p = 0.067
VPA is considered to exert its deleterious effects on the fetal brain through several distinct mechanisms, such as alterations of -aminobutyric acid signaling, the inhibition of histone deacetylase, the disruption of folic acid metabolism, and the activation of mammalian target of rapamycin
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Additionally, the treated mice had lower blood glucose levels and increased insulin sensitivity and glucose transporter 4 expression levels
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