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However, there are some differences between the two forms of supplementation: Absorption : B complex injections are typically more effective at increasing blood levels of the B vitamins than oral supplements because they bypass the digestive system and are absorbed directly into the bloodstream

Possible explanations for how HRT could adversely affect MASLD development include adverse effects from the progesterone component of HRT (which is infrequently considered in existing studies), nonphysiologically high hepatic estrogen exposure from oral estrogens, and the inability to replicate the natural oscillatory patterns of hepatic estrogen exposure in the premenopausal state (10)