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medRxiv 11 , 25340314 (2025)

Learning to evaluate information critically and focus on evidence-based guidance helps people benefit from community support without being derailed by outlier experiences

Women who were taking both HRT and tirzepatide had: A greater median percentage weight loss (17% vs 14%) A higher rate of achieving 20%+ weight loss (45% vs 18%) These findings suggest that concomitant HRT may positively influence weight loss response when using incretin-based therapies like tirzepatide

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Those with pre-existing eye conditions should inform their healthcare provider, though routine eye screening is not specifically required for patients without diabetes or known eye disease