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Furthermore, therapeutic agents targeting mitochondrial enzymes such as SHMT2, PDH, and CPT1A remain largely in preclinical or early-phase clinical development, with limited data available on optimal delivery strategies, pharmacokinetics, and safety profiles [24]
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Godwin-Austen et al., 1971
KRAS signalling has been linked to enhanced mitochondrial metabolism by various mechanisms in colorectal, lung and pancreatic cancers 8,18 , as has APC and p53 (refs
Dorant E, van den Brandt PA, Goldbohm RA (1995) Allium vegetable consumption, garlic supplement intake, and female breast carcinoma incidence
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