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Intriguingly, emerging evidence suggests that some newer agents such as ocrelizumab (a B cell-depleting monoclonal antibody) and siponimod (a sphingosine 1-phosphate receptor modulator with anti-inflammatory and neuroprotective properties) are beneficial in progressive MS, potentially with effects independent of suppressing acute inflammation (Montalban et al., 2017

Statistical analysis was performed by one-way analysis of variance (ANOVA) followed by Tukeys post hoc test using Minitab 16 and Students t-test

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This structural simplicity initially suggested it might have oral bioavailability, though research has not consistently supported this assumption

For individuals who struggle with excessive hunger or disordered eating patterns, GLP-1 agonists may be more appropriate