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In that study it was shown that both PIO and TOFO for 24 weeks significantly improved hepatic steatosis based on the absolute change in MRI-proton density fat fraction (MRI-PDFF), as well as ALT levels, with the differences being statistically insignificant between the two drugs

Special Populations Effect of Age Neonates Children within the first two months of life have a markedly decreased ability to eliminate valproate compared to older children and adults

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pain, physical abuse or malnutrition) and emotional stress (e.g