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Crush together, cover with water, and refrigerate

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When phentermine and topiramate were co-administered to rats at doses of 3.75 and 25 mg/kg, respectively [approximately 2 times the maximum recommended human dose (MRHD) based on area under the curve (AUC)], or at the same dose to rabbits (approximately 0.1 times and 1 time, respectively, the clinical exposures at the MRHD based on AUC), there were no drug-related malformations

Collectively, these results indicate that LEO exerts a protective effect by increasing GLP-1 in mice with T2D

The number is made up of a four-digit year, followed by a seven-digit sequence, followed by a two-character Kind Code (e.g., US20170232019A1)