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I have always thought, along with other colleagues for a long time, that you can start identifying groups that have lived with obesity for a very long period of time and they would somehow present differently metabolically and so on, and it would give us an understanding of what treatments would be better for someone, let's say, with long-term obesity versus someone with short-term obesity

Sometimes your body composition improves without dramatic scale changes, particularly if youre building muscle while losing fat

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In the past, we looked at diseases in silos

Figure 20: Photograph of Gyula Taktsy taken on a study tour in Warsaw in 1972 (credit: Wikipedia) and Taktsy's loop (credit: Astle)