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While IV ketamine remains an off-label treatment, high-quality evidence continues to support its use for patients experiencing treatment-resistant depression and acute suicidal symptoms under appropriate medical supervision

Mice not pretreated with buthionine sulfoximine, but administered GSH, experienced an increase in plasma GSH, but not tissue GSH

On ice, cells were scraped and collected in extraction buffer containing methanol:acetonitrile:H 2 O (4:4:2), 15 M glutaric acid and 0.5% formic acid

3k), in part reflecting lower baseline values for these parameters in Gipr Syn/ mice