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States With No Coverage for Obesity-Indicated GLP-1s: In 14 states and the District of Columbia, Medicaid programs do not cover GLP-1s for obesity
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Finally, individuals with a history of heart failure, ischaemic heart disease, unstable angina, myocardial infarction, aortic aneurysm or dissection, stroke (ischaemic or haemorrhagic stroke), cerebral infarction, transient ischaemic attack, carotid intervention or surgery, coronary stenting, percutaneous coronary intervention (PCI) or coronary artery bypass before inclusion to the cohort or prior to the index event were also excluded
Data suggests that this could involve modulation of urea cycle enzymes in the liver and changes in messenger RNA expression