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The glutathione peroxidase gpx4 prevents lipid peroxidation and ferroptosis to sustain treg cell activation and suppression of antitumor immunity

Western blot results revealed a lower expression of CD31 and VEGF- in the ischemic tissues of GSDMD -/- mice compared to controls (Fig

Additionally, GF mice exhibit a decreased count of CD4+ T cells in their spleens, along with a reduction in both the number and size of germinal centers within the spleen, implying that the GM plays a crucial role in modulating systemic immunity (121) ( Table 2 )

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Inoue et al., 2012