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According to previous studies by Park et al (121) and Lee et al (122), terrein, a novel fungal metabolite reduces TYR expression by downregulating MITF in a manner that is dependent on ERK activation, with its inhibitory effects on melanin synthesis prolonged by ubiquitin-mediated proteasomal degradation

Nanocarrier-mediated drugs targeting cancer stem cells: an emerging delivery approach

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GCL catalyzes the first, and rate-controlling, step of the pathway that creates a linkage between glutamate and cysteine via the -carboxyl residue of the latter to produce -glutamylcysteine [56]

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