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Kidney disease is also extremely common in people with type 1 diabetes

High-risk groups can exhibit different responses after GLP-1 cessation

As these medications gain wider use, patients understandably ask whether they affect liver and kidney functiontwo organs that process and eliminate medications from the body

Research has identified multiple pathways through which semaglutide impairs normal stomach function: Direct inhibition of gastric motility through vagus nerve modulation Disruption of gastric pacemaker cells that coordinate stomach contractions Impaired gastric accommodation in the fundus and body regions Antral hypomotility preventing proper food grinding and propulsion Dysregulation of pyloric sphincter relaxation blocking stomach emptying Alterations in small intestinal motility affecting the entire digestive process Clinical data reveals that up to 75% of patients with normal gastric emptying before receiving GLP-1 agonists developed delayed gastric emptying after treatment initiation, with some studies showing 30% experiencing severe delays qualifying as gastroparesis

The approval is valid through 31 December 2027 and covers subsequent refills and dose adjustments without requiring a new authorisation, unless the beneficiary switches from one covered GLP-1 drug to a different one